The Mammalian Body in Captivity: Neurobiology, Physiology, and the Architecture of Decline

Alex Applebee and A. D. Masters

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A Unified Thesis on Evolutionary Mismatch, Movement, Social Connection, and Unconscious Motivation

Authors: Alex Applebee and A. D. Masters

OMXUS Research, Perth, Western Australia, 2026

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Author's Note

This document exists because of three goals that sound eccentric until you read the evidence behind them.

Goal 10 (food proven safe) (food proven safe): Food contains only things proven safe.

Goal 11 (physical infrastructure) (physical infrastructure): Monkey bars at every bus stop. Climbing walls on all stairwells.

Goal 14 (cancer prevention) (cancer prevention): Cancer is 90% preventable. Here's how.

These goals were not derived from policy brainstorming. They were derived from biology. From the simple observation that the human body is not a machine that breaks down. It is a mammalian system that deteriorates when its environmental requirements are not met.

Every pathology has an evolutionary context. Type 2 diabetes is not a disease of sugar. It is a disease of metabolic mismatch -- a body adapted for intermittent food availability confronting constant caloric surplus. Lower back pain is not a design flaw. It is a consequence of a spine adapted for variable terrain being locked into a seated position for ten hours a day. Depression is not a chemical imbalance in a broken brain. It is an inflammatory response in a body deprived of movement, sunlight, social contact, and purpose -- every one of which has measurable physiological pathways that the evidence base has now mapped in detail.

The conventional medical model treats each of these as a separate problem requiring a separate pharmaceutical intervention. The evolutionary model treats them a